The effect of stressful life events on the risk for psychosis: differences between Mexican at clinical and familial high risk.

Background: Stressful life events (SLEs) in the development of early psychosis have been little studied in low-income countries. This study examines differences in the prevalence of SLEs in Mexican at clinical high risk (CHR) and those with familial high risk for psychosis who do not meet CHR criteria (non-CHR FHR). We also analyze the association between SLEs and CHR. Methods: Participants included 43 persons with CHR and 35 with non-CHR FHR. CHR criteria were assessed with the Comprehensive Assessment of At-Risk Mental State. SLEs were assessed using the Questionnaire of Stressful Life Events. Results: Participants with CHR reported more SLEs associated with negative academic experiences than those in the non-CHR FHR group. Bullying (OR = 7.77, 95% CI [1.81, 33.32]) and low educational level (OR = 21.25, 95% CI [5.19, 46.90]) were the strongest predictors of CHR, while starting to live with a partner (OR = 0.26, 95% CI [0.10, 0.84]) was associated with a lower risk of CHR. Conclusion: Negative school experiences increase the risk of psychosis, particularly bullying, suggesting that schools may be ideal settings for implementing individual preventive strategies to reduce risk factors and increase protective factors to improve the prognosis of those at risk of developing psychosis. In Latin America, there are multiple barriers to early intervention in psychosis. It is thus crucial to identify risk and protective factors at the onset and in the course of psychosis in order to design effective preventive interventions.

Psychosocial factors associated with the risk of developing psychosis in a Mexican general population sample.

Epidemiological evidence has linked an array of sociodemographic and psychosocial factors with an increased risk of developing psychosis. However, research in samples from low- and middle-income countries is still scarce. This study used a Mexican sample to explore (i) sociodemographic and psychosocial differences between individuals with and without a positive screen for Clinical High-Risk for psychosis (CHR), and (ii) sociodemographic and psychosocial factors associated with screening positive for CHR. The sample consisted of 822 individuals from the general population who completed an online survey. Of the participants, 17.3% (n = 142) met the CHR screening criteria. Comparisons between those who screened positive (CHR-positive group) and those who did not (Non-CHR group) showed that participants in the CHR-positive group were younger, had a lower educational level, and reported more mental health problems than the Non-CHR group. Furthermore, relative to the Non-CHR group, the CHR-positive group had a greater prevalence of medium/high risk associated with cannabis use, a higher prevalence of adverse experiences (bullying, intimate partner violence, and experiencing a violent or unexpected death of a relative or friend), as well as higher levels of childhood maltreatment, poorer family functioning, and more distress associated with the COVID-19 pandemic. Groups did not differ in sex, marital/relationship status, occupation, and socio-economic status. Finally, when examined in multivariate analyses, the variables associated with screening positive for CHR were: having an unhealthy family functioning (OR = 2.75, 95%CI 1.69-4.46), a higher risk associated with cannabis use (OR = 2.75, 95%CI 1.63-4.64), a lower level of education (OR = 1.55, 95%CI 1.003-2.54), having experienced a major natural disaster (OR = 1.94, 95%CI 1.18-3.16), having experienced a violent or unexpected death of a relative or friend (OR = 1.85, 95%CI 1.22-2.81), higher levels of childhood emotional abuse (OR = 1.88, 95%CI 1.09-3.25), physical neglect (OR = 1.68, 95%CI 1.08-2.61), and physical abuse (OR = 1.66, 95%CI 1.05-2.61), and higher COVID-related distress (OR = 1.10, 95%CI 1.01-1.20). An older age was a protective factor for screening positive for CHR (OR = 0.96, 95%CI 0.92-0.99). Overall, the findings highlight the importance of examining potential psychosocial contributors to psychosis vulnerability across different sociocultural contexts to delineate risk and protective processes relevant to specific populations and better target preventive intervention efforts.

Why Do Some People Become More Involved in Cannabis Use Than Others? A Systematic Narrative Review on Cannabis Use Transition Predictors.

OBJECTIVE: Given the increased legislative changes toward cannabis use around the globe and the negative consequences of cannabis misuse for public health and safety, a greater understanding of cannabis use transitions is important to guide decision-making. Although evidence on cannabis use-associated factors is vast, studies on the factors influencing the incidence and progression of cannabis use over time are still relatively scarce. This study presents a systematic narrative review of studies focused on longitudinal predictors of cannabis use in order to summarize the state of the field, identify research gaps, and propose avenues for future research. METHOD: We searched for prospective observational studies that examined factors associated with the initiation, increase, or other longitudinal patterns of cannabis use in the general population, published up to December 2020 and indexed in EBSCOhost, PubMed, and Google Scholar. RESULTS: Of the 31 included studies in this review, most focused on intrapersonal, interpersonal, and socioenvironmental factors. The most consistent predictors of cannabis use transitions across studies were previous patterns of other substance use, mental health and personality traits, family and peer influences, and other factors such as ethnicity and education. CONCLUSIONS: We identified a lack of consensus on the definition of outcome variables, objective measures of cannabis use, and international representativeness among the included studies, as none of them was carried out in developing countries. For research to have a greater impact on prevention, treatment, and public policy, more longitudinal studies are needed to increase knowledge of causal mechanisms and the predictive power of risk and protective factors for cannabis use problems.

Clinical and Functional Differences Between Mexican Youth at Clinical High Risk for Psychosis and With Familial High Risk.

Few studies have explored the differences in clinical psychopathology between youth at high risk for psychosis and those at familial high risk for psychosis. This study seeks to describe and compare the sociodemographic, clinical, and functional characteristics of At-Risk Mental State (ARMS) for psychosis youth and those with a first- or second-degree relative with psychosis (Familial High-Risk: FHR) in a Mexican sample. Twenty-one ARMS individuals and 21 with FHR were evaluated for sociodemographic characteristics, psychopathological symptoms, and functional impairment. ARMS individuals were significantly younger, had fewer years of schooling, and were more likely to be male than those in the FHR group. Groups did not differ as regards marital status or occupation. The ARMS group showed greater severity of prodromal symptoms, schizotypal personality traits, and general psychopathology than the FHR group. In addition, they reported more premorbid adjustment deficit from early adolescence than the FHR group. Current overall social and role functioning was significantly lower in the ARMS group. Findings are consistent with ARMS studies from other countries. First- or second-degree relatives of patients with psychosis should be considered a vulnerable group as they display several symptoms of general psychopathology and may experience social adjustment problems in their adult lives. The lack of early detection and intervention psychosis programs in Mexico underlines the need to prioritize the development of preventive strategies to help close the care gap.

Confirmatory Factor Analysis of the Transgender Knowledge, Attitudes, and Beliefs (T-KAB) Scale for the Mexican Population.

Transphobia is a result of the widespread lack of knowledge among the general population, together with prejudice based on irrational fear and hatred, of those who do not fit the dominant, socially established gender categories. Little is known about transgender-related knowledge, attitudes, and beliefs among the Mexican population, due to the lack of reliable, valid Spanish-language instruments. This study presents a Spanish translation of the Transgender Knowledge, Attitudes, and Beliefs (T-KAB) Scale and examines its psychometric properties for the Mexican population. A cohort of 501 adult subjects, 337 (67.3%) women and 161 (32.1%) men, drawn from the general population, answered the T-KAB in an anonymous online survey. A confirmatory factor analysis (CFA) and internal consistency measure were used to determine whether its dimensions were reliable and valid for use in a Mexican Spanish language and cultural context. A CFA including the three original dimensions proposed and excluding one item from the T-KAB Scale showed appropriate goodness of fit indices (χ2(180) = 389.41; χ2/df = 2.16, RMSEA = 0.048, CI [0.042, 0.055]; CFI = 0.971; TLI = 0.966), with Cronbach's alpha values over 0.85. The psychometric properties exhibited by the Spanish version of the T-KAB support its use for the assessment of knowledge, attitudes, and beliefs regarding transgender people in the Mexican cultural context. This instrument offers researchers a brief, reliable, valid, and easy self-report measure to use in further studies in Spanish-speaking populations.

Exploring Mental Health Professionals' Experiences of Intimate Partner Violence-Related Training: Results From a Global Survey.

Intimate partner violence (IPV) is a global public health problem that has been shown to lead to serious mental health consequences. Due to its frequent co-occurrence with psychiatric disorders, it is important to assess for IPV in mental health settings to improve treatment planning and referral. However, lack of training in how to identify and respond to IPV has been identified as a barrier for the assessment of IPV. The present study seeks to better understand this IPV-related training gap by assessing global mental health professionals' experiences of IPV-related training and factors that contribute to their likelihood of receiving training. Participants were French-, Spanish-, and Japanese-speaking psychologists and psychiatrists (N = 321) from 24 nations differing on variables related to IPV, including IPV prevalence, IPV-related norms, and IPV-related laws. Participants responded to an online survey asking them to describe their experiences of IPV-related training (i.e., components and hours of training) and were asked to rate the frequency with which they encountered IPV in clinical practice and their level of knowledge and experience related to relationship problems; 53.1% of participants indicated that they had received IPV-related training. Clinicians from countries with relatively better implemented laws addressing IPV and those who encountered IPV more often in their regular practice were more likely to have received training. Participants who had received IPV-related training, relative to those without training, were more likely to report greater knowledge and experience related to relationship problems. Findings suggest that clinicians' awareness of IPV and the institutional context in which they practice are related to training. Training, in turn, is associated with subjective appraisals of knowledge and experience related to relationship problems. Increasing institutional efforts to address IPV (e.g., implementing IPV legislation) may contribute to improved practices with regard to IPV in mental health settings.

Family environmental factors in at-risk mental states for psychosis.

The family environment represents an important psychosocial factor that impacts psychosis prognosis, but little is known about its effect on the at-risk stages of psychosis. This study presents a comprehensive review and summarizes the state of the art of study on the wide range of family factors related to family functioning in the At-Risk Mental State (ARMS) for psychosis, as well as family interventions in ARMS individuals. Publications were retrieved by an extensive search on MEDLINE, PsycINFO and SCOPUS (1990-2020). Expressed Emotion is the most studied variable in ARMS literature, but there is scarce evidence of the role of other significant family factors at the ARMS stage. Overall, high Expressed Emotion did not appear to be reactive to ARMS patients' poor clinical status. However, initial evidence has suggested that relatives' beliefs about the disorder may play a significant role, either as mediators of these relationships or as predictors of Expressed Emotion. Available literature yet to yield a consistent pattern of findings on the association between Expressed Emotion or other family functioning indicators and negative outcomes, but some longitudinal studies highlight the greater potential for the protective effects of positive family environments at the ARMS stage. Family-based interventions have demonstrated benefits for both ARMS individuals and family dynamics. An increased focus on the impact of the at-risk stage of illness on relatives' mental well-being is required to provide family support based on their needs and to clarify the mechanisms leading to dysfunctional family dynamics during the critical ARMS period.

Evaluating the Relationship Between Intimate Partner Violence-Related Training and Mental Health Professionals' Assessment of Relationship Problems.

Intimate partner violence (IPV) is a serious public health problem associated with increased risk of developing mental health conditions. Assessment of IPV in mental health settings is important for appropriate treatment planning and referral; however, lack of training in how to identify and respond to IPV presents a significant barrier to assessment. To address this issue, the World Health Organization (WHO) advanced a series of evidence-based recommendations for IPV-related training programs. This study examines the relationship between mental health professionals' experiences of IPV-related training, including the degree to which their training resembles WHO training recommendations, and their accuracy in correctly identifying relationship problems. Participants were psychologists and psychiatrists (N = 321) from 24 countries who agreed to participate in an online survey in French, Japanese, or Spanish. They responded to questions regarding their IPV-related training (i.e., components and hours of training) and rated the presence or absence of clinically significant relationship problems and maltreatment (RPM) and mental disorders across four case vignettes. Participants who received IPV-related training, and whose training was more recent and more closely resembled WHO training recommendations, were more likely than those without training to accurately identify RPM when it was present. Clinicians regardless of IPV-related training were equally likely to misclassify normative couple issues as clinically significant RPM. Findings suggest that IPV-related training assists clinicians in making more accurate assessments of patients presenting with clinically significant relationship problems, including IPV. These data inform recommendations for IPV-related training programs and suggest that training should be repeated, multicomponent, and include experiential training exercises, and guidelines for distinguishing normative relationship problems from clinically significant RPM.

Accuracy of diagnostic judgments using ICD-11 vs. ICD-10 diagnostic guidelines for obsessive-compulsive and related disorders.

BACKGROUND: We report results of an internet-based field study evaluating the diagnostic guidelines for the newly introduced ICD-11 grouping of obsessive-compulsive and related disorders (OCRD). We examined accuracy of clinicians' diagnostic judgments applying draft ICD-11 as compared to the ICD-10 diagnostic guidelines to standardized case vignettes. METHODS: 1,717 mental health professionals who are members of the World Health Organization's Global Clinical Practice Network completed the study in Chinese, English, French, Japanese, Russian or Spanish. Participants were randomly assigned to apply ICD-11 or ICD-10 guidelines to one of nine pairs of case vignettes. RESULTS: Participants using ICD-11 outperformed those using ICD-10 in correctly identifying newly introduced OCRD, although results were mixed for differentiating OCRD from disorders in other groupings largely due to clinicians having difficulty differentiating challenging presentations of OCD. Clinicians had difficulty applying a three-level insight qualifier, although the 'poor to absent' level assisted with differentiating OCRD from psychotic disorders. Brief training on the rationale for an OCRD grouping did not improve diagnostic accuracy suggesting sufficient detail of the proposed guidelines. LIMITATIONS: Standardized case vignettes were manipulated to include specific characteristics; the degree of accuracy of clinicians' diagnostic judgments about these vignettes may not generalize to application in routine clinical practice. CONCLUSIONS: Overall, use of the ICD-11 guidelines resulted in more accurate diagnosis of case vignettes compared to the ICD-10 guidelines, particularly in differentiating OCRD presentations from one another. Specific areas in which the ICD-11 guidelines did not perform as intended provided the basis for further revisions to the guidelines.

Predictors of criticism and emotional over-involvement in relatives of early psychosis patients.

Mechanisms underlying the manifestation of relatives' expressed emotion (EE) in the early stages of psychosis are still not properly understood. The present study aimed to examine whether relatives' psychological distress and subjective appraisals of the illness predicted EE dimensions over-and-above patients' poor clinical and functional status. Baseline patient-related variables and relatives attributes comprising criticism, emotional over-involvement (EOI), psychological distress, and illness attributions were assessed in 91 early psychosis patients and their respective relatives. Relatives were reassessed regarding EE dimensions at a 6-month follow-up. Relatives' psychological distress and illness attributions predicted criticism and EOI over-and-above patients' illness characteristics at both time points. Relatives' increased levels of anxiety, attributions of blame toward the patients, an emotional negative representation about the disorder, and decreased levels of self-blame attributions predicted EE-criticism at baseline. Relatives' anxiety and negative emotional representation of the disorder were the only significant predictors of EE-criticism at follow-up, whereas anxiety, attributions of control by the relative and an emotional negative representation about the disorder predicted EE-EOI both at baseline and follow-up assessments. Understanding the components that comprise and maintain EE attitudes should guide early psychosis caregivers in family interventions, enhancing proper management of psychological distress and reduction of negative appraisals about the illness. The prevention of high-EE attitudes over time in a sensitive period such as early psychosis might be critical in shaping the health of caregivers and the outcome of the affected relatives.

Interaction of both positive and negative daily-life experiences with FKBP5 haplotype on psychosis risk.

BACKGROUND: There is limited research on the interaction of both positive and negative daily-life environments with stress-related genetic variants on psychotic experiences (PEs) and negative affect (NA) across the extended psychosis phenotype. This study examined whether the FK506 binding protein 51 (FKBP5) variability moderates the association of positive and negative experiences in the moment with PEs and NA in participants with incipient psychosis and their nonclinical counterparts. METHODS: A total of 233 nonclinical and 86 incipient psychosis participants were prompted for a 1-week period to assess their day-to-day experiences. Participants were genotyped for four FKBP5 single nucleotide polymorphisms (rs3800373, rs9296158, rs1360780, and rs9470080). RESULTS: Multilevel analyses indicated that, unlike the risk haplotype, the protective FKBP5 haplotype moderated all the associations of positive experiences with diminished PEs and NA in incipient psychosis compared with nonclinical group. CONCLUSIONS: Participants with incipient psychosis showed symptomatic improvement when reporting positive appraisals in the interpersonal domain, which suggests that these act as a powerful coping mechanism. The fact that this occurred in daily-life underscores the clinical significance of this finding and pinpoints the importance of identifying protective mechanisms. In addition, results seem to concur with the vantage sensitivity model of gene-environment interaction, which poses that certain genetic variants may enhance the likelihood of benefiting from positive exposures.

Ecological Validity of Expressed Emotion in Early Psychosis.

Expressed emotion (EE) is an aspect of the family environment that influences the course of multiple forms of psychopathology. However, there is limited research about how EE dimensions [i.e., criticism and emotional over-involvement (EOI)] are expressed in real-world settings. The present study used experience sampling methodology to investigate: 1) the criterion and construct validity of daily-life, momentary measures of criticism and EOI, and 2) the construct and ecological validity of psychometric EE-dimensions as assessed with the self-report Family Questionnaire (FQ). A total sample of 55 relatives (34 relatives of at-risk mental state patients and 21 of first-episode psychosis patients) were prompted randomly six times daily for 1-week to assess their current emotional experiences and cognitive appraisals. Relatives also completed the FQ. Momentary criticism and EOI were significantly associated with the two FQ-EE dimensions respectively, supporting the criterion validity of real-world assessed EE dimensions. As hypothesized, momentary and FQ-EE dimensions were associated with decreased positive affect, as well as with appraisals of less effective coping in daily life. Only momentary EE dimensions were associated with increased momentary negative affect. Partly in contrast with our hypotheses, momentary criticism and FQ-criticism were more consistently related to situational stress and burden than momentary EOI and FQ-EOI. Finally, neither momentary nor FQ-EE dimensions showed distinct patterns of associations with illness attributions. Findings partly support the construct validity of momentary criticism and EOI as well as the construct and ecological validity of the FQ as a sensitive measure of EE dimensions.

Relatives' attachment anxiety mediates the association between perceived loss and expressed emotion in early psychosis.

A common reaction experienced by family members of patients with psychosis is grief for the loss of their healthy relative. Importantly, high levels of perceived loss have been related to the manifestation of high expressed emotion (EE), which includes the negative attitudes expressed by relatives toward an ill family member. However, the mechanisms underlying the relationship between relatives' perceived loss and EE attitudes in the early stages of psychosis are still not fully understood. In this regard, attachment theory has been suggested as a useful framework for understanding this link. The current study aimed to examine: (1) whether relatives' perceived loss was associated with relatives' EE dimensions (i.e., criticism and emotional over-involvement (EOI)), and (2) whether such associations were mediated by relatives' attachment dimensions (i.e., anxiety and avoidance). Seventy-eight relatives of patients with early psychosis completed the Mental Illness Version of the Texas Inventory of Grief for the assessment of loss reactions. Attachment dimensions and EE attitudes were assessed by the Psychosis Attachment Measure and the Family Questionnaire, respectively. Findings indicated that relatives' perceived loss was associated with EE dimensions. Relatives' attachment anxiety, but not avoidance, mediated the relationship of perceived loss with both criticism and EOI. Findings highlight the importance of examining the role of relatives' attachment characteristics for understanding how perceptions of loss might impact the manifestation of EE attitudes in the early stages of psychosis. Family interventions aimed at assisting relatives to improve their management of negative emotional reactions to loss are fundamental to prevent impairing loss reactions and the entrenchment of high-EE attitudes.

Gender differences of patients at-risk for psychosis regarding symptomatology, drug use, comorbidity and functioning - Results from the EU-GEI study.

BACKGROUND: Gender differences in symptomatology in chronic schizophrenia and first episode psychosis patients have often been reported. However, little is known about gender differences in those at risk of psychotic disorders. This study investigated gender differences in symptomatology, drug use, comorbidity (i.e. substance use, affective and anxiety disorders) and global functioning in patients with an at-risk mental state (ARMS) for psychosis. METHODS: The sample consisted of 336 ARMS patients (159 women) from the prodromal work package of the EUropean network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI; 11 centers). Clinical symptoms, drug use, comorbidity and functioning were assessed at first presentation to an early detection center using structured interviews. RESULTS: In unadjusted analyses, men were found to have significantly higher rates of negative symptoms and current cannabis use while women showed higher rates of general psychopathology and more often displayed comorbid affective and anxiety disorders. No gender differences were found for global functioning. The results generally did not change when corrected for possible cofounders (e.g. cannabis use). However, most differences did not withstand correction for multiple testing. CONCLUSIONS: Findings indicate that gender differences in symptomatology and comorbidity in ARMS are similar to those seen in overt psychosis and in healthy controls. However, observed differences are small and would only be reliably detected in studies with high statistical power. Moreover, such small effects would likely not be clinically meaningful.

Anxiety and Fear-Related Disorders in the ICD-11: Results from a Global Case-controlled Field Study.

BACKGROUND: This article reports the results of one of a series of global field studies implemented by the World Health Organization (WHO) to evaluate the accuracy, clinical utility, and global applicability of the new diagnostic guidelines for Mental, Behavioural and Neurological Disorders included in the next version of WHO's International Classification of Diseases (ICD-11). AIMS OF THE STUDY: The purpose of this study was to compare the diagnostic accuracy and clinical utility ratings of global clinicians implementing the ICD-11 diagnostic guidelines for Anxiety and Fear-Related Disorders, relative to those applying ICD-10 guidelines. The study also aimed to identify elements of the guidelines that required further refinement or clarification. METHODS: 1840 global mental health professionals registered with WHO's Global Clinical Practice Network completed the study in one of six study languages. Participants were randomly assigned to apply either the ICD-11 or ICD-10 guidelines to diagnose standardized case vignettes, and to rate the clinical utility of their assigned guidelines. RESULTS: ICD-11's diagnostic accuracy and clinical utility were equivalent or superior to that of ICD-10. Global clinicians were significantly more accurate in diagnosing Generalized Anxiety Disorder, Specific Phobia and adult cases of Separation Anxiety Disorder when using ICD-11 and provided high clinical utility ratings for these disorders. Clinicians also found the ICD-11 guidelines easy to use, clear, and a good fit to patients they see in their clinical practice. However, clinicians had difficulty with distinguishing the boundary between disorder and normality for subthreshold cases of anxiety, and also with applying the new ICD-11 guidelines on panic attacks. CONCLUSIONS: The new diagnostic guidelines for Anxiety Disorders in ICD-11 can be applied in an acceptably consistent manner by global clinicians and perform as well or better than the previous guidelines for ICD-10. Study findings also helped identify aspects of the ICD-11 guidelines that required refinement prior to their publication and areas that should be emphasized in training programs.

Preventing Transphobic Bullying and Promoting Inclusive Educational Environments: Literature Review and Implementing Recommendations.

BACKGROUND: Transgender individuals are often targets of abuse, bullying, harassment, discrimination and violence at school, which causes significant personal suffering and serious consequences for their education process. Research suggests that structural interventions and changes are needed to reduce these phenomena and ensure that schools function as protective and secure learning environments for sexual minorities. AIM: This study presents a review of international interventions/programs focused on reducing bullying and promoting inclusive educational environments for transgender youths. METHODS: An extensive literature search in English and Spanish was undertaken using the electronic database of MEDLINE, PsycINFO, SCOPUS, SciELO and LILACS (1990-2018). RESULTS: Several international programs, guidelines and projects aimed at preventing bullying against sexual minorities (including the transgender population) in school environments were described. Recommendations and barriers to consider in the development and implementation of bullying prevention interventions in a range of school settings are discussed. CONCLUSIONS: Evidence suggest important positive benefits associated with attending schools that have anti-bullying or inclusive policies for gender minorities, such as the improvement of school wellbeing, more positive school climate, decreasing truancy, lower levels of victimization, decreased school harassment and increased feelings of safety. However, more research is needed to follow up on the various programs and interventions described in this study, to determine whether they have been implemented and what their actual long-term impact has been. The normalization of transphobia and tolerance for sexual minorities requires the attention of public policies in education strategies designed to deconstruct gender stereotypes and eradicate transphobia among adolescents.

Clinical utility of ICD-11 diagnostic guidelines for high-burden mental disorders: results from mental health settings in 13 countries.

In this paper we report the clinical utility of the diagnostic guidelines for ICD-11 mental, behavioural and neurodevelopmental disorders as assessed by 339 clinicians in 1,806 patients in 28 mental health settings in 13 countries. Clinician raters applied the guidelines for schizophrenia and other primary psychotic disorders, mood disorders (depressive and bipolar disorders), anxiety and fear-related disorders, and disorders specifically associated with stress. Clinician ratings of the clinical utility of the proposed ICD-11 diagnostic guidelines were very positive overall. The guidelines were perceived as easy to use, corresponding accurately to patients' presentations (i.e., goodness of fit), clear and understandable, providing an appropriate level of detail, taking about the same or less time than clinicians' usual practice, and providing useful guidance about distinguishing disorder from normality and from other disorders. Clinicians evaluated the guidelines as less useful for treatment selection and assessing prognosis than for communicating with other health professionals, though the former ratings were still positive overall. Field studies that assess perceived clinical utility of the proposed ICD-11 diagnostic guidelines among their intended users have very important implications. Classification is the interface between health encounters and health information; if clinicians do not find that a new diagnostic system provides clinically useful information, they are unlikely to apply it consistently and faithfully. This would have a major impact on the validity of aggregated health encounter data used for health policy and decision making. Overall, the results of this study provide considerable reason to be optimistic about the perceived clinical utility of the ICD-11 among global clinicians.

The ICD-11 developmental field study of reliability of diagnoses of high-burden mental disorders: results among adult patients in mental health settings of 13 countries.

Reliable, clinically useful, and globally applicable diagnostic classification of mental disorders is an essential foundation for global mental health. The World Health Organization (WHO) is nearing completion of the 11th revision of the International Classification of Diseases and Related Health Problems (ICD-11). The present study assessed inter-diagnostician reliability of mental disorders accounting for the greatest proportion of global disease burden and the highest levels of service utilization - schizophrenia and other primary psychotic disorders, mood disorders, anxiety and fear-related disorders, and disorders specifically associated with stress - among adult patients presenting for treatment at 28 participating centers in 13 countries. A concurrent joint-rater design was used, focusing specifically on whether two clinicians, relying on the same clinical information, agreed on the diagnosis when separately applying the ICD-11 diagnostic guidelines. A total of 1,806 patients were assessed by 339 clinicians in the local language. Intraclass kappa coefficients for diagnoses weighted by site and study prevalence ranged from 0.45 (dysthymic disorder) to 0.88 (social anxiety disorder) and would be considered moderate to almost perfect for all diagnoses. Overall, the reliability of the ICD-11 diagnostic guidelines was superior to that previously reported for equivalent ICD-10 guidelines. These data provide support for the suitability of the ICD-11 diagnostic guidelines for implementation at a global level. The findings will inform further revision of the ICD-11 diagnostic guidelines prior to their publication and the development of programs to support professional training and implementation of the ICD-11 by WHO member states.

WHODAS and the evaluation of disability among people with mental disorders with and without psychotic symptoms / El WHODAS y la evaluación de discapacidad en personas con trastornos mentales con y sin síntomas psicóticos

Abstract Introduction Valid and feasible measures to properly assess the most impaired areas of functioning in various groups of patients with mental disorders would allow the development and evaluation of interventions designed to modify the specific environmental barriers that contribute to patients´ disability. Objective This article seeks to evaluate the internal consistency and construct and convergent validity of the Spanish version of the World Health Organization's Disability Assessment Schedule WHODAS 2.0, as well as its relationship with sociodemographic variables and symptomatic severity in Mexican patients with and without psychotic symptoms. Method The WHODAS 2.0 and the Social and Occupational Functioning Assessment Scale SOFAS were administered to 153 patients with any of the following diagnoses: affective disorders, anxiety disorders, stress-related disorders, and psychotic disorders. Results The WHODAS 2.0 showed high internal consistency in patients with psychotic symptoms (Cronbach's alpha = .92) and without psychotic symptoms (Cronbach's alpha = .89). Nevertheless, only in patients without psychotic symptoms, was a significant negative correlation between WHODAS (disability) and SOFAS (functioning) total scores observed, together with significant differences in WHODAS scores between those with mild and severe symptomatology. Discussion and conclusion The WHODAS 2.0 is an adequate measure of disability in patients without psychotic symptoms. It could be used as a complementary measure of disability in those with psychotic symptoms. Further studies are required to determine other psychometric properties of the WHODAS 2.0, particularly those related to temporal stability and sensitivity to change.

Resumen Introducción Disponer de medidas válidas y confiables para evaluar las áreas de funcionamiento más comprometidas en los diferentes grupos de pacientes con trastornos mentales permitiría el desarrollo y la evaluación de intervenciones dirigidas a modificar barreras específicas del contexto que contribuyen a su deterioro funcional. Objetivo Evaluar la consistencia interna y la validez de constructo y convergente de la versión en español del cuestionario para la evaluación de discapacidad de la Organización Mundial de la Salud WHODAS 2.0, así como su relación con variables demográficas y la gravedad sintomática en pacientes mexicanos con y sin síntomas psicóticos. Método El WHODAS y la escala de evaluación del funcionamiento social y ocupacional SOFAS se aplicaron a una muestra de 153 pacientes con algún diagnóstico de trastorno afectivo, de ansiedad, relacionado con el estrés o psicótico. Resultados El WHODAS mostró alta consistencia interna en pacientes con síntomas psicóticos (alpha de Cronbach = .92) y en aquellos sin síntomas psicóticos (alpha de Cronbach = .89). Sin embargo, sólo en los pacientes sin síntomas psicóticos se observó una correlación negativa entre las puntuaciones del WHODAS 2.0 (discapacidad) y el SOFAS (funcionalidad) así como diferencias significativas en las puntuaciones WHODAS de aquellos con sintomática leve y grave. Discusión y conclusión La escala WHODAS 2.0 es adecuada para medir discapacidad en pacientes sin síntomas psicóticos. En aquellos con síntomas psicóticos, podría servir más bien con fines complementarios. Se sugieren estudios para determinar otras propiedades psicométricas del WHODAS, especialmente las relacionadas con su estabilidad temporal y sensibilidad al cambio.

Características clínicas y psicosociales de pacientes con Estados Mentales de Alto Riesgo y Primeros Episodios de Psicosis de un Programa de Psicosis Incipiente en Barcelona (España) / Clinical and Psychosocial Characterization of At-Risk Mental State and Recent Onset Psychosis Patients from an Early Psychosis Program in Barcelona (Spain)

Introducción. Este estudio tiene como objetivo describir y comparar las características sociodemográficas, clínicas y psicosociales, así como los antecedentes de tratamiento y uso de servicios, de pacientes con Estados Mentales de Alto Riesgo (EMAR) y Primeros Episodios de Psicosis (PEP) del Programa de Psicosis Incipiente-Sant Pere Claver (PPI-SPC) en Barcelona. Metodología. 43 EMAR y 40 pacientes PEP fueron evaluados con numerosos instrumentos clínicos y psicosociales al inicio del estudio. Resultados. Las características clínicas y psicosociales de la muestra del PPI-SPC fueron comparables con las de estudios previos de psicosis incipiente. Las características sociodemográficas, clínicas y los antecedentes fueron similares entre los grupos de pacientes. Como era de esperar, los grupos EMAR y PEP mostraron diferencias significativas en los antecedentes de tratamientos psiquiátricos previos, hospitalizaciones y tratamiento psiquiátrico actual. La edad de inicio de los síntomas inespecíficos, los síntomas prodrómicos y la edad de inicio del primer tratamiento especializado fue anterior en los pacientes EMAR que en los PEP. Los pacientes PEP mostraron mayores puntuaciones en los síntomas positivos y cognitivos, y mayor gravedad global sintomatológica que los pacientes EMAR. Los pacientes EMAR mostraron mayores puntuaciones en manía, sintomatología general y un deterioro ligeramente mayor del funcionamiento premórbido desde la adolescencia temprana que los PEP. Conclusiones. Los resultados apoyan la noción de que los pacientes EMAR que buscan atención pueden considerarse como una población con un deterioro psicosocial importante y con necesidad de tratamiento, ya que padecen de múltiples alteraciones mentales y funcionales. Estos resultados respaldan la conveniencia de los esfuerzos actuales de detección e intervención temprana en esta población (AU)

Introduction. This study aimed to describe and compare socio-demographic, background, treatment history, and service use, psychopathological and psychosocial characteristics of At-Risk Mental States (ARMS) and First-Episode Psychosis (FEP) patients from the Sant Pere Claver-Early Psychosis Program (SPC-EPP) in Barcelona. Methods. 43 ARMS-patients and 40 FEP-patients were assessed with several clinical and psychosocial measures at study baseline. Results. Clinical and psychosocial characteristics of the SPC-EPP sample were comparable to those of previous early psychosis studies. Overall, the socio-demographic and clinical background characteristics appeared to be mostly similar between ARMS and FEP patients. As expected, groups differed on history of previous psychiatric hospitalizations and current psychiatric treatment. The age at onset of both unspecific and prodromal symptoms, and age of first specialized psychiatric/psychological treatment were earlier in ARMS than in FEP-patients. FEP-patients showed higher scores on positive symptoms, cognitive and greater overall symptom severity than ARMS-patients. ARMS-patients showed higher scores on mania, general psychopathology and a slightly lower premorbid functioning since early-adolescence than FEP-patients. Conclusions. Findings support the notion that ARMS-patients who seek for help can be considered as already highly dysfunctional and in need of treatment, given that they already suffer from multiple mental and functional disturbances. This supports current health care efforts in providing early access to treatment to this population and signals the need to sustain pilot early detection efforts (AU)